Nigrostriatal function in humans studied with positron emission tomography
Identifieur interne : 004A94 ( Main/Exploration ); précédent : 004A93; suivant : 004A95Nigrostriatal function in humans studied with positron emission tomography
Auteurs : Richard L. Martin [Canada] ; M. R. Palmer [Canada] ; C. S. Patlak [États-Unis] ; D. B. CalneSource :
- Annals of Neurology [ 0364-5134 ] ; 1989-10.
Abstract
The dopamine depletion that is characteristic of Parkinson's disease has been hypothesized to result from the combination of environmentally induced subclinical damage to the substantia nigra and the age‐related loss of additional nigral neurons. Essential to this hypothesis is the existence of deteriorating function in the nigrostriatal pathway with advancing age. The present study was undertaken with [18F]6‐fluoro‐L‐dopa and positron emission tomography to determine in vivo the effects of age on the nigrostriatal pathway in a series of 10 asymptomatic subjects (age range, 22–80 years; mean, 49.8 years). A graphical approach was used in the analysis of multiple‐time tracer‐uptake data to establish the presence of a compartment with unidirectional uptake and to calculate the rate constant, K, for uptake of [18F]6‐fluoro‐L‐dopa from blood to striatum during steady‐state, an index of the functional integrity of nigrostriatal nerve endings. There was a significant linear relationship between K and age (r = 0.80, p < 0.005) with a decrease of 53.3% over the age range studied. These results demonstrate the application of a unidirectional transfer model to the analysis of [18F]6‐fluoro‐L‐dopa and positron emission tomography data and provide in vivo confirmation of an age‐related impairment of nigrostriatal function.
Url:
DOI: 10.1002/ana.410260407
Affiliations:
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Martin</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia/TRIUMF Positron Emission Tomography Program, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University Hospital, 2211 Wesbrook Mall, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, M R" sort="Palmer, M R" uniqKey="Palmer M" first="M. R." last="Palmer">M. R. 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Calne</name><affiliation><wicri:noCountry code="subField">Columbia</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1989-10">1989-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="535">535</biblScope><biblScope unit="page" to="542">542</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">A24AA56F272E3A483C3724CCCDF6079C6C44E100</idno><idno type="DOI">10.1002/ana.410260407</idno><idno type="ArticleID">ANA410260407</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The dopamine depletion that is characteristic of Parkinson's disease has been hypothesized to result from the combination of environmentally induced subclinical damage to the substantia nigra and the age‐related loss of additional nigral neurons. Essential to this hypothesis is the existence of deteriorating function in the nigrostriatal pathway with advancing age. The present study was undertaken with [18F]6‐fluoro‐L‐dopa and positron emission tomography to determine in vivo the effects of age on the nigrostriatal pathway in a series of 10 asymptomatic subjects (age range, 22–80 years; mean, 49.8 years). A graphical approach was used in the analysis of multiple‐time tracer‐uptake data to establish the presence of a compartment with unidirectional uptake and to calculate the rate constant, K, for uptake of [18F]6‐fluoro‐L‐dopa from blood to striatum during steady‐state, an index of the functional integrity of nigrostriatal nerve endings. There was a significant linear relationship between K and age (r = 0.80, p < 0.005) with a decrease of 53.3% over the age range studied. These results demonstrate the application of a unidirectional transfer model to the analysis of [18F]6‐fluoro‐L‐dopa and positron emission tomography data and provide in vivo confirmation of an age‐related impairment of nigrostriatal function.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name></noCountry><country name="Canada"><noRegion><name sortKey="Martin, Richard L" sort="Martin, Richard L" uniqKey="Martin R" first="Richard L." last="Martin">Richard L. Martin</name></noRegion><name sortKey="Martin, Richard L" sort="Martin, Richard L" uniqKey="Martin R" first="Richard L." last="Martin">Richard L. Martin</name><name sortKey="Palmer, M R" sort="Palmer, M R" uniqKey="Palmer M" first="M. R." last="Palmer">M. R. Palmer</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Patlak, C S" sort="Patlak, C S" uniqKey="Patlak C" first="C. S." last="Patlak">C. S. Patlak</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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